| Date | Game |
| Tue, Nov 27 | No. 13 North Carolina at No. 1 Indiana |
| No. 6 NC State at No. 5 Michigan | |
| No. 25 Minnesota at Florida State | |
| Maryland at Northwestern | |
| Iowa at Virginia Tech | |
| Nebraska at Wake Forest | |
| Wed, Nov 28 | No. 8 Ohio State at No. 15 Duke |
| Virginia at No. 22 Wisconsin | |
| No. 9 Michigan State at Miami | |
| Purdue at Clemson | |
| Georgia Tech at Illinois | |
| Boston College at Penn State |
FSU to host Minnesota as part of 2012 ACC/Big Ten Challenge
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